2009, ISBN: 9783639164008

[ED: Taschenbuch / Paperback], [PU: VDM Verlag Dr. Müller], Nitric oxide (NO) produced by endothelial nitric oxide synthase (eNOS) is a key mediator of vascular homeostasis. eNOS enzymati… Mehr…

[ED: Taschenbuch / Paperback], [PU: VDM Verlag Dr. Müller], Nitric oxide (NO) produced by endothelial nitric oxide synthase (eNOS) is a key mediator of vascular homeostasis. eNOS enzymatic activity appears to be determined by the availability of its cofactor tetrahydrobiopterin (BH4). BH4 bioavailability is limited by oxidative degradation in dysfunctional endothelium, and by alterations in the rate of its biosynthesis, governed by the rate-limiting enzyme GTP cyclohydrolase 1 (GTPCH). In this project novel targeted transgenic mouse lines were generated with endothelial-specific over-expression of human GTPCH. These studies have shown that BH4 bioavailability within the endothelium is essential for maintaining NO synthesis and reducing superoxide production by eNOS in vivo. Modest persistent increases in endothelial cell BH4 concentration by increased biosynthesis are sufficient to maintain NO bioavailability and endothelial function, even in the setting of vascular oxidative stress. These findings suggest that strategies to augment endothelial BH4 levels, either by increased biosynthesis or by reducing BH4 oxidation, may be valuable in preventing and treating vascular disease., DE, [SC: 0.00], Neuware, gewerbliches Angebot, 140, [GW: 200g], Selbstabholung und Barzahlung, PayPal, offene Rechnung, Banküberweisung, Internationaler Versand<

ISBN: 9783639164008

Nitric oxide (NO) produced by endothelial nitric oxide synthase (eNOS) is a key mediator of vascular homeostasis. eNOS enzymatic activity appears to be determined by the availability of i… Mehr…

Nitric oxide (NO) produced by endothelial nitric oxide synthase (eNOS) is a key mediator of vascular homeostasis. eNOS enzymatic activity appears to be determined by the availability of its cofactor tetrahydrobiopterin (BH4). BH4 bioavailability is limited by oxidative degradation in dysfunctional endothelium, and by alterations in the rate of its biosynthesis, governed by the rate-limiting enzyme GTP cyclohydrolase 1 (GTPCH). In this project novel targeted transgenic mouse lines were generated with endothelial-specific over-expression of human GTPCH. These studies have shown that BH4 bioavailability within the endothelium is essential for maintaining NO synthesis and reducing superoxide production by eNOS in vivo. Modest persistent increases in endothelial cell BH4 concentration by increased biosynthesis are sufficient to maintain NO bioavailability and endothelial function, even in the setting of vascular oxidative stress. These findings suggest that strategies to augment endothelial BH4 levels, either by increased biosynthesis or by reducing BH4 oxidation, may be valuable in preventing and treating vascular disease. Buch / Broschur, [PU: VDM Verlag Dr. Müller, Saarbrücken]<

2009, ISBN: 9783639164008

Erscheinungsdatum: 06/2009, Medium: Taschenbuch, Einband: Kartoniert / Broschiert, Titel: Tetrahydrobiopterin and nitric oxide synthase regulation, Titelzusatz: Generation and analysis of… Mehr…

Erscheinungsdatum: 06/2009, Medium: Taschenbuch, Einband: Kartoniert / Broschiert, Titel: Tetrahydrobiopterin and nitric oxide synthase regulation, Titelzusatz: Generation and analysis of endothelial-targetedtransgenic mouse lines over-expressing human GTP cyclohydrolase 1, Autor: Alp, Nicholas, Verlag: VDM Verlag, Sprache: Englisch, Rubrik: Medizin // Allgemeines, Lexika, Seiten: 140, Informationen: Paperback, Gewicht: 225 gr, Verkäufer: averdo Sachbücher, [PU: VDM Verlag Dr. Müller, Saarbrücken]<

2009, ISBN: 3639164008

Gebundene Ausgabe

Generation and analysis of endothelial-targetedtransgenic mouse lines over-expressing human GTP cyclohydrolase 1 - Buch, gebundene Ausgabe, 140 S., Beilagen: Paperback, Erschienen: 2009 V… Mehr…

Generation and analysis of endothelial-targetedtransgenic mouse lines over-expressing human GTP cyclohydrolase 1 - Buch, gebundene Ausgabe, 140 S., Beilagen: Paperback, Erschienen: 2009 VDM Verlag, [PU: VDM Verlag Dr. Müller, Saarbrücken]<

2009, ISBN: 3639164008

Kartoniert / Broschiert, mit Schutzumschlag neu, [PU:VDM Verlag]