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ISBN: 9780470057667

Editor: Chadwick, Derek J. Editor: Goode, Jamie A. Wiley, Hardcover, Auflage: 8, 286 Seiten, Publiziert: 2007-06-05T00:00:01Z, Produktgruppe: Book, 0.58 kg, Verkaufsrang: 10755199, Test P… Mehr…

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Acetaldehyde-Related Pathology - gebunden oder broschiert

2007, ISBN: 9780470057667

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Acetaldehyde-Related Pathology
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9780470057667


Acetaldehyde contributes to pathologies ranging from cancer to asthma. It affects the whole body, the architecture of the cell and molecular control mechanisms. The origins of acetaldehyde vary from bacteria in the oral cavity and intestinal tract to atmospheric acetaldehyde as an environmental pollutant. Significant amounts of acetaldehyde are also derived from cigarette smoke and alcohol, both of which are major contributors to disease globally. Acetaldehyde has deleterious effects in the liver, brain and skeletal muscle. It has also been shown that bacteria can generate significant amounts of acetaldehyde in the gastrointestinal tract, thus contributing to carcinogenesis in this tissue. Many of the toxic effects of ethanol ingestion are mediated through acetaldehyde and there is increasing awareness that acetaldehyde is a principal disease-forming agent in tobacco-related illnesses. Alcohol is metabolized by conversion to acetaldehyde, which in turn is converted to acetate by aldehyde dehydrogenase (ALDH). There are a number of forms of ALDH of which the mitochondrial isoform (ALDH2) is particularly important. The ALDH2 gene has a functional polymorphism: homozygous subjects have little or no ALDH2 activity compared to their wild-type counterparts. Heterozygotes generally also have low ALDH2 activity. Epidemiological studies have found increased risk of certain diseases, including cancer of the gastrointestinal tract, alcoholic liver disease and late-onset Alzheimer's disease in subjects with ALDH2 deficiency. This book features contributions from researchers working on all aspects of acetaldehyde-related pathology. From their expert accounts and the lively discussions accompanying each chapter, we can derive a better understanding of the pathogenesis of diseases in which acetaldehyde, from whichever source, is implicated.

Detailangaben zum Buch - Acetaldehyde-Related Pathology


EAN (ISBN-13): 9780470057667
ISBN (ISBN-10): 0470057661
Gebundene Ausgabe
Erscheinungsjahr: 2007
Herausgeber: John Wiley & Sons Inc
275 Seiten
Gewicht: 0,585 kg
Sprache: eng/Englisch

Buch in der Datenbank seit 2008-05-27T01:41:52+02:00 (Vienna)
Detailseite zuletzt geändert am 2023-10-19T07:41:08+02:00 (Vienna)
ISBN/EAN: 9780470057667

ISBN - alternative Schreibweisen:
0-470-05766-1, 978-0-470-05766-7
Alternative Schreibweisen und verwandte Suchbegriffe:
Autor des Buches: novartis, goode, chadwick, foundation
Titel des Buches: bridging the divide, acetaldehyde, trans, upon this foundation, novartis

Daten vom Verlag:

Titel: Novartis Foundation Symposium; Acetaldehyde-Related Pathology - Bridging the Trans-Disciplinary Divide, No. 285
Verlag: John Wiley & Sons
286 Seiten
Erscheinungsjahr: 2007-04-20
Gewicht: 0,588 kg
Sprache: Englisch
199,00 € (DE)
No longer receiving updates
152mm x 229mm x 18mm

BB; gebunden; Hardcover, Softcover / Biologie/Mikrobiologie; Biologie, Biowissenschaften; Toxikologie; Biochemistry (Chemical Biology); Pharmacology & Pharmaceutical Medicine; Biowissenschaften; Cell & Molecular Biology; Zell- u. Molekularbiologie; Biochemie u. Chemische Biologie; Chemistry; Medizin; Medical Science; Pharmakologie u. Pharmazeutische Medizin; Life Sciences; Toxicology; Biochemie; Chemie; Biochemie u. Chemische Biologie; Zell- u. Molekularbiologie; Toxikologie; Pharmakologie u. Pharmazeutische Medizin

Symposium on Acetaldehyde-related pathology: bridging the trans-disciplinary divide, held at the Novartis Foundation, London 5-7th September. Editors: Derek J. Chadwick (Organizer) and Jamie Goode This symposium is based on a proposal made by Victor Preedy, Peter Emery and Mikko Salaspuro Peter Emery Chair's introduction. David W. Crabb and Suthat Liangpunsakul Acetaldehyde generating enzyme systems: roles of alcohol dehydrogenase, CYP2E1 and catalase, and speculations on the role of other enzymes and processes. Discussion. Richard A. Deitrich, Dennis Petersen and Vasilis Vasiliou Removal of acetaldehyde from the body. Discussion. Shih-Jiun Yin and Giia-Sheun Peng Acetaldehyde, polymorphisms and the cardiovascular system. Discussion. Jun Ren Acetaldehyde and alcoholic cardiomyopathy: lessons from the ADH and ALDH2 transgenic models. Discussion. Mikko Salaspuro Interrelationship between alcohol, smoking, acetaldehyde and cancer. Discussion. Hiroto Matsuse, Chizu Fukushima, Terufumi Shimoda, Sadahiro Asai and Shigeru Kohno Effects of acetaldehyde on human airway constriction and infl ammation. Discussion. Helmut K. Seitz The role of acetaldehyde in alcohol-associated cancer of the gastrointestinal tract. Discussion. Robert Tardif The determination of acetaldehyde in exhaled breath. Discussion. Mostofa Jamal, Kiyoshi Ameno, Mitsuru Kumihashi, Weihuan Wang, Ikuo Uekita and Iwao Ijiri Ethanol and acetaldehyde: in vivo quantitation and effects on cholinergic function in rat brain. Discussion. Ville Salaspuro Pharmacological treatments and strategies for reducing oral and intestinal acetaldehyde. Discussion. Victor R. Preedy, David W. Crabb, Jaume Farrés and Peter W. Emery Alcoholic myopathy and acetaldehyde. Discussion. Onni Niemelä Acetaldehyde adducts in circulation. Discussion. General discussion. M. Apte, J. McCarroll, R. Pirola and J. Wilson Pancreatic MAP kinase pathways and acetaldehyde. Discussion. Shivendra D. Shukla, Youn Ju Lee, Pil-hoon Park and Annayya R. Aroor Acetaldehyde alters MAP kinase signalling and epigenetic histone modifi cations in hepatocytes. Discussion. Paul J. Thornalley Endogenous alpha-oxoaldehydes and formation of protein and nucleotide advanced glycation endproducts in tissue damage. Discussion. C. J. Peter Eriksson Measurement of acetaldehyde: what levels occur naturally and in response to alcohol? Discussion. Final discussion. Contributors Index. Subject Index.

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