2010, ISBN: 3639278380

[EAN: 9783639278385], Neubuch, [PU: VDM Verlag Dr. Müller], nach der Bestellung gedruckt Neuware - Printed after ordering - Mitochondria are often referred to as the cellular powerhouse d… Mehr…

[EAN: 9783639278385], Neubuch, [PU: VDM Verlag Dr. Müller], nach der Bestellung gedruckt Neuware - Printed after ordering - Mitochondria are often referred to as the cellular powerhouse due to their key function in the process of oxidative phosphorylation. But side reactions of the electron transport chain are implemented in the generation of reactive oxygen species. These ROS are highly reactive and cause damage to biological molecules. The free radical theory of ageing hypothesizes that such damage is the primary mechanism of ageing. Therefore the search for proteins that are targets of damage is of critical importance to understand the role of oxidative stress in ageing. Proteomics combined with MS provides a powerful suite of techniques for the identification of these proteins. We focused on the development and refinement of a proteomic workflow aiming to produce a high quality quantitative survey of the mitochondrial proteome. We performed qualitative LC-MS/MS-based experiments on mitochondria proteins by means of both gel-based and gel-free approaches, showing an over 4-fold increase in protein identifications by the latter. In addition first quantitative results were collected, yielding in the quantitation of 599 proteins, illustrating the potential of the developed method and the acquired data. 96 pp. Englisch, Books<

2010, ISBN: 9783639278385

[ED: Softcover], [PU: VDM Verlag Dr. Müller], Mitochondria are often referred to as the cellular powerhouse due to their key function in the process of oxidative phosphorylation. But side… Mehr…

[ED: Softcover], [PU: VDM Verlag Dr. Müller], Mitochondria are often referred to as the cellular powerhouse due to their key function in the process of oxidative phosphorylation. But side reactions of the electron transport chain are implemented in the generation of reactive oxygen species. These ROS are highly reactive and cause damage to biological molecules. The free radical theory of ageing hypothesizes that such damage is the primary mechanism of ageing. Therefore the search for proteins that are targets of damage is of critical importance to understand the role of oxidative stress in ageing. Proteomics combined with MS provides a powerful suite of techniques for the identification of these proteins. We focused on the development and refinement of a proteomic workflow aiming to produce a high quality quantitative survey of the mitochondrial proteome. We performed qualitative LC-MS/MS-based experiments on mitochondria proteins by means of both gel-based and gel-free approaches, showing an over 4-fold increase in protein identifications by the latter. In addition first quantitative results were collected, yielding in the quantitation of 599 proteins, illustrating the potential of the developed method and the acquired data. 2010. 96 S. Versandfertig in 6-10 Tagen, DE, [SC: 0.00], Neuware, gewerbliches Angebot, Offene Rechnung (Vorkasse vorbehalten)<

2010, ISBN: 3639278380

[EAN: 9783639278385], Neubuch, [PU: VDM Verlag Dr. Müller], This item is printed on demand - it takes 3-4 days longer - Neuware -Mitochondria are often referred to as the cellular powerho… Mehr…

[EAN: 9783639278385], Neubuch, [PU: VDM Verlag Dr. Müller], This item is printed on demand - it takes 3-4 days longer - Neuware -Mitochondria are often referred to as the cellular powerhouse due to their key function in the process of oxidative phosphorylation. But side reactions of the electron transport chain are implemented in the generation of reactive oxygen species. These ROS are highly reactive and cause damage to biological molecules. The free radical theory of ageing hypothesizes that such damage is the primary mechanism of ageing. Therefore the search for proteins that are targets of damage is of critical importance to understand the role of oxidative stress in ageing. Proteomics combined with MS provides a powerful suite of techniques for the identification of these proteins. We focused on the development and refinement of a proteomic workflow aiming to produce a high quality quantitative survey of the mitochondrial proteome. We performed qualitative LC-MS/MS-based experiments on mitochondria proteins by means of both gel-based and gel-free approaches, showing an over 4-fold increase in protein identifications by the latter. In addition first quantitative results were collected, yielding in the quantitation of 599 proteins, illustrating the potential of the developed method and the acquired data. 96 pp. Englisch, Books<

ISBN: 9783639278385

gewerbliches Angebot, [SC: 0.00], Neuware, [PU: VDM Verlag Dr. Müller], 96, [GW: 145g], [ED: Taschenbuch], DE, Mitochondria are often referred to as the cellular powerhouse due to their k… Mehr…

gewerbliches Angebot, [SC: 0.00], Neuware, [PU: VDM Verlag Dr. Müller], 96, [GW: 145g], [ED: Taschenbuch], DE, Mitochondria are often referred to as the cellular powerhouse due to their key function in the process of oxidative phosphorylation. But side reactions of the electron transport chain are implemented in the generation of reactive oxygen species. These ROS are highly reactive and cause damage to biological molecules. The free radical theory of ageing hypothesizes that such damage is the primary mechanism of ageing. Therefore the search for proteins that are targets of damage is of critical importance to understand the role of oxidative stress in ageing. Proteomics combined with MS provides a powerful suite of techniques for the identification of these proteins. We focused on the development and refinement of a proteomic workflow aiming to produce a high quality quantitative survey of the mitochondrial proteome. We performed qualitative LC-MS/MS-based experiments on mitochondria proteins by means of both gel-based and gel-free approaches, showing an over 4-fold increase in protein..., Banküberweisung, PayPal, [CT: Sonstiges / Sonstiges]<

2010, ISBN: 9783639278385

Gebundene Ausgabe

[ED: Kartoniert / Broschiert], [PU: VDM Verlag Dr. Mueller], Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Autor/Autorin: Hueber BjoernD… Mehr…

[ED: Kartoniert / Broschiert], [PU: VDM Verlag Dr. Mueller], Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Autor/Autorin: Hueber BjoernDipl. Ing.: Process and bioengineering studies at the University of Applied Sciences Offenburg, Germany. Thesis at the North East Pr, DE, [SC: 0.00], Neuware, gewerbliches Angebot, Hardcover, 96, [GW: 161g], 1. Auflage, Banküberweisung, PayPal<