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Effect of Curcumin on BOP Induced Oxidative Stress in a Hamster Model: Correlation with Metabolomic Profile - Zaheeruddin, Shaistha
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Effect of Curcumin on BOP Induced Oxidative Stress in a Hamster Model: Correlation with Metabolomic Profile - Taschenbuch

2010, ISBN: 9783838379845

LAP LAMBERT Academic Publishing, Paperback, 104 Seiten, Publiziert: 2010-12-01T00:00:01Z, Produktgruppe: Book, 0.16 kg, Diseases & Disorders, Internal Medicine, Medical & Healthcare Pract… Mehr…

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Shaistha Zaheeruddin:

Effect of Curcumin on Bop Induced Oxidative Stress in a Hamster Model - Taschenbuch

2010, ISBN: 3838379845

[EAN: 9783838379845], Neubuch, [PU: LAP LAMBERT Academic Publishing], 104 pages. 8.66x5.91x0.24 inches. In Stock., Books

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Shaistha Zaheeruddin:
Effect of Curcumin on Bop Induced Oxidative Stress in a Hamster Model - Taschenbuch

ISBN: 9783838379845

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Effect of Curcumin on BOP Induced Oxidative Stress in a Hamster Model: Correlation with Metabolomic Profile - Taschenbuch

ISBN: 9783838379845

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Shaistha Zaheeruddin:
Effect of Curcumin on Bop Induced Oxidative Stress in a Hamster Model - Taschenbuch

2010, ISBN: 9783838379845

Softcover, Neubuch, [PU: LAP LAMBERT Academic Publishing]

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Details zum Buch
Effect of Curcumin on BOP Induced Oxidative Stress in a Hamster Model: Correlation with Metabolomic Profile

Oxidative stress (OS) is associated with many chronic states including cancer. Curcumin, a bioactive chemical of turmeric has potent antioxidant effects. We utilized metabolomics to evaluate signatures of OS in BOP (N-nitrosobis-2-(oxopropyl) amine) induced hamsters and their effect by curcumin. 32 hamsters were randomized into treatment (n=20; OS induced by BOP) and control (n=12) groups. After 12 weeks each group was subdivided by no (T0, C0) or 2% curcumin (T2, C2) diet. Proton nuclear magnetic resonance spectroscopy was conducted on urine and analyzed using Principal Component Analysis PCA;SIMCA P+, Umetrics. The PCA score plots showed clear separation between spectra from treatment (T0) and control (C0) groups, and curcumin fed (T2) groups (p0.05). Partial Least Square (PLS) analysis correlated the metabolomic profiles with Total Antioxidant, cyclooxygenase-2 and NF-kB activity well. Metabolites responsible for the inter-group differences were linked to the pyrimidine, purine and glycine, serine and threonine pathways. With further investigation these metabolites, in addition to providing a mechanistic insight, may serve as potential signatures of OS.

Detailangaben zum Buch - Effect of Curcumin on BOP Induced Oxidative Stress in a Hamster Model: Correlation with Metabolomic Profile


EAN (ISBN-13): 9783838379845
ISBN (ISBN-10): 3838379845
Taschenbuch
Erscheinungsjahr: 2010
Herausgeber: LAP LAMBERT Academic Publishing
104 Seiten
Gewicht: 0,171 kg
Sprache: eng/Englisch

Buch in der Datenbank seit 2011-06-01T02:26:54+02:00 (Vienna)
Detailseite zuletzt geändert am 2022-01-26T22:32:09+01:00 (Vienna)
ISBN/EAN: 9783838379845

ISBN - alternative Schreibweisen:
3-8383-7984-5, 978-3-8383-7984-5


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