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Cancer Biology and the Nuclear Envelope : Recent Advances May Elucidate Past Paradoxes - Jose I. De Las Heras
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2014, ISBN: 1489980318

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Cancer Biology and the Nuclear Envelope / Recent Advances May Elucidate Past Paradoxes / Jose I. De Las Heras (u. a.) / Buch / Advances in Experimental Medicine and Biology / XIII / Englisch / 2014 - De Las Heras, Jose I.
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Cancer Biology and the Nuclear Envelope / Recent Advances May Elucidate Past Paradoxes / Jose I. De Las Heras (u. a.) / Buch / Advances in Experimental Medicine and Biology / XIII / Englisch / 2014 - gebunden oder broschiert

2014, ISBN: 9781489980311

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Cancer Biology and the Nuclear Envelope: Recent Advances May Elucidate Past Paradoxes (Advances in Experimental Medicine and Biology, 773, Band 773)
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Cancer Biology and the Nuclear Envelope: Recent Advances May Elucidate Past Paradoxes (Advances in Experimental Medicine and Biology, 773, Band 773) - gebunden oder broschiert

2014

ISBN: 9781489980311

Springer, Gebundene Ausgabe, Auflage: 2014, 624 Seiten, Publiziert: 2014-02-23T00:00:01Z, Produktgruppe: Buch, Hersteller-Nr.: 14 black & white illustrations, 84 colou, 25.83 kg, Medizin,… Mehr…

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Cancer Biology and the Nuclear Envelope Recent Advances May Elucidate Past Paradoxes - De Las Heras, Jose I. (Herausgeber); Schirmer, Eric C. (Herausgeber)
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De Las Heras, Jose I. (Herausgeber); Schirmer, Eric C. (Herausgeber):
Cancer Biology and the Nuclear Envelope Recent Advances May Elucidate Past Paradoxes - gebunden oder broschiert

2014, ISBN: 1489980318

2014 Gebundene Ausgabe Biomedizin, Medizin / Biomedizin, Krebs (Krankheit), Tumor / Krebs, Eiweiß (chemisch), Protein, Onkologie, Mikrobiologie und Virologie, Biochemie, Zellbiologie (Z… Mehr…

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Cancer Biology and the Nuclear Envelope - Schirmer, Eric C.|Heras, Jose I. de las
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Schirmer, Eric C.|Heras, Jose I. de las:
Cancer Biology and the Nuclear Envelope - gebunden oder broschiert

2014, ISBN: 1489980318

[EAN: 9781489980311], Neubuch, [SC: 0.0], [PU: Springer New York], BIOMEDIZIN MEDIZIN KREBS (KRANKHEIT) TUMOR EIWEISS (CHEMISCH) PROTEIN DNA CELLCYCLEREGULATION NUCLEARENVELOPE SIGNALLING… Mehr…

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Details zum Buch
Cancer Biology and the Nuclear Envelope: Recent Advances May Elucidate Past Paradoxes (Advances in Experimental Medicine and Biology, 773, Band 773)
Autor:
Titel:
ISBN-Nummer:

9781489980311


"Nuclear envelope (NE) defects have been linked to cancer biology since the mid-1800s, but it was not until the last few years that we have begun to understand these historical links and to realize that there are myriad ways that the NE impacts on tumorigenesis. The NE is a complex double membrane system that encloses the genome while providing structural support through the intermediate filament lamin polymer and regulating protein/ mRNA trafficking and signaling between the nucleus and cytoplasm via the nuclear pore complexes (NPCs). These functions already provide some mechanisms for NE influences on cancer biology but work in the past few years has elucidated many others. Lamins and many recently identified NE transmembrane proteins (NETs) have been now shown to function in DNA repair, regulation of cell cycle and signaling, apoptosis, cell migration in metastasis and nuclear architecture and morphology. This volume presents a comprehensive overview of the wide range of functions recently identified for NE proteins and their relevance in cancer biology, providing molecular mechanisms and evidence of their value as prognostic and diagnostic markers and suggesting new avenues for the treatment of cancer. Indeed some of these recent links are already yielding promising therapies, such as the current clinical trial of selective inhibitors of the nuclear export factor exportin in certain types of leukemia, melanoma and kidney cancer."

Detailangaben zum Buch - Cancer Biology and the Nuclear Envelope: Recent Advances May Elucidate Past Paradoxes (Advances in Experimental Medicine and Biology, 773, Band 773)


EAN (ISBN-13): 9781489980311
ISBN (ISBN-10): 1489980318
Gebundene Ausgabe
Erscheinungsjahr: 2014
Herausgeber: Schirmer, Eric C. de las Heras, Jose I. Springer

Buch in der Datenbank seit 2014-03-05T19:08:00+01:00 (Vienna)
Detailseite zuletzt geändert am 2024-03-08T09:50:03+01:00 (Vienna)
ISBN/EAN: 9781489980311

ISBN - alternative Schreibweisen:
1-4899-8031-8, 978-1-4899-8031-1
Alternative Schreibweisen und verwandte Suchbegriffe:
Autor des Buches: heras, schirmer, schirm
Titel des Buches: recent advances, the biology cancer, paradoxes, nuclear medicine and biology, advances experimental medicine and biology

Daten vom Verlag:

Autor/in: Eric C. Schirmer
Titel: Advances in Experimental Medicine and Biology; Cancer Biology and the Nuclear Envelope - Recent Advances May Elucidate Past Paradoxes
Verlag: Springer; Springer US
611 Seiten
Erscheinungsjahr: 2014-02-23
New York; NY; US
Gedruckt / Hergestellt in Niederlande.
Sprache: Englisch
219,99 € (DE)

BB; Hardcover, Softcover / Medizin/Nichtklinische Fächer; Onkologie; Verstehen; DNA; cell cycle regulation; nuclear envelope; signalling; stress response; Cancer Biology; Medical Microbiology; Protein Biochemistry; Membrane Trafficking; Biomedical Research; Mikrobiologie und Virologie; Biochemie; Zellbiologie (Zytologie); Medizinische Forschung; EA; BC

Section I: History and use of the nuclear envelope in cancer prognosis: Overview and perspective.- Cancer and the nuclear envelope, a history and perspective.- The role of the nuclear lamina in cancer and apoptosis.- The diagnostic pathology of the nuclear envelope in human cancers.- Nuclear morphometry, epigenetic changes, and clinical relevance in prostate cancer.- "To be or not to be in good shape": diagnostic and clinical value of nuclear shape irregularities in thyroid and breast cancer.- Section II: The nuclear envelope in cell cycle regulation and signaling.- pRb and lamins in cell cycle regulation and aging.- Lamina-associated polypeptide (LAP)2a and other LEM proteins in cancer biology.- NETs and cell cycle regulation.- Nuclear envelope regulation of signaling cascades.- Section III: Nuclear envelope regulation of the genome.- Nuclear envelope - connecting structural genome organization to regulation of gene expression.- Studying lamins in invertebrate models.- Lamin organization of chromosome positioning.- Section IV: Functions of the NPC in cancer.- NPC proteins linked in cancer overview.- Roles of the nucleoporin Tpr in cancer and aging.- Ran GTPase in nuclear envelope formation and cancer metastasis.- Wnt signaling proteins associate with the nuclear pore complex: implications for cancer.- Section V: The nuclear envelope in DNA damage and stress responses.- DNA damage and lamins.- Repo-Man at the intersection of chromatin remodeling, DNA repair, nuclear envelope organization and cancer progression.- Lamines and oxygen stress damage in cell proliferation.- Section VI: The nuclear envelope link to cell migration and metastasis.- Nuclear mechanics in cancer.- Nuclear envelope in nuclear positioning and cell migration.- Nesprins in cell stability and migration.- Connecting the nucleus to the cytoskeleton for nuclear positioning and call migration.- Section VII: Towards a molecular explanation of prognostic links to the nuclear envelope.-Nuclear envelope invaginations and cancer.- Mechanisms of nuclear size regulation in model systems and cancer.- Control of nuclear size by NPC proteins.- Do lamins influence disease progression in cancer?.   
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