ISBN: 9783527633258

Concepts, Syntheses, Characterization, Modeling and Applications InhaltsangabePreface.List of Contributors.1 The Basic Idea and the Drivers (Nobuo Tanaka and Klaus K. Unger).1.1 Definitio… Mehr…

Concepts, Syntheses, Characterization, Modeling and Applications InhaltsangabePreface.List of Contributors.1 The Basic Idea and the Drivers (Nobuo Tanaka and Klaus K. Unger).1.1 Definitions.1.2 Monoliths as Heterogeneous Catalysts.1.3 Monoliths in Chromatographic Separations.1.4 Conclusion and Perspectives.References.Part One Preparation.2 Synthesis Concepts and Preparation of Silica Monoliths (Kazuki Nakanishi).2.1 Introduction.2.2 Background and Concepts.2.3 Synthesis of Silica Monoliths.2.4 Monolithic Columns Prepared in the Laboratory.2.5 Summary.References.3 Preparation and Properties of Various Types of Monolithic Silica Stationary Phases for Reversed-Phase, Hydrophilic Interaction, and Ion-Exchange Chromatography Based on Polymer-Coated Materials (Oscar Nunez and Tohru Ikegami).3.1 Stationary Phases for Reversed-Phase Chromatography.3.2 Stationary Phases for Hydrophilic-Interaction Chromatography Separations.3.3 Stationary Phases for Ion-Exchange Separations.3.4 Advantages of Polymer-Coated Monolithic Silica Columns.References.Part Two Characterization and Modeling.4 Characterization of the Pore Structure of Monolithic Silicas (Romas Skudas, Matthias Thommes, and Klaus K. Unger).4.1 Monolithic Silicas.4.2 General Aspects Describing Porous Materials.4.3 Characterization Methods of the Pore Structure of Monolithic Silicas.4.4 Comparison of the Silica Monolith Mesopore-Characterization Data.4.5 Comparison of the Silica Monolith Flow-Through Pore-Characterization Data.References.5 Microscopic Characterizations (Haruko Saito, Kazuyoshi Kanamori, and Kazuki Nakanishi).5.1 Introduction.5.2 Preparation of Macroporous Silica Monolith.5.3 Laser Scanning Confocal Microscope Observation.5.4 Image Processing.5.5 Fundamental Parameters.5.6 Three-Dimensional Observation of Deformations in Confined Geometry.References.6 Modeling Chromatographic Band Broadening in Monolithic Columns (Frederik Detobel and Gert Desmet).6.1 Introduction.6.2 The General Plate-Height Model.6.3 Use of the General Plate-Height Model to Predict Band Broadening in TSM Structures.6.4 Conclusion.Acknowledgments.Symbols.Greek Symbols.Subscripts.References.7 Comparison of the Performance of Particle-Packed and Monolithic Columns in High-Performance Liquid Chromatography (Georges Guiochon).7.1 Introduction.7.2 Basic Columns Properties.7.3 Comparison of the Through-Pore Structures and Related Properties.7.4 Thermodynamic Properties.7.5 Kinetic Propertie Solutes.9.4 Contribution of Overload to Peak Shapes of Basic Solutes.9.5 Van Deemter Plots for Commercial Monoliths.9.6 Performance of Hybrid Capillary Silica Monoliths for Basic Compounds.9.7 Conclusions.References.10 Quality Control of Drugs (Mohammed Taha, Abdelkarem Abed, and Sami El Deeb).10.1 Introduction.10.2 Analysis of Pharmaceutics.10.3 Natural Products Analysis.10.4 Analysis Speed and Performance.10.5 Method Transfer.10.6 Separation of Complex Mixtures.10.7 Monolith Derivatives and Versatile Application.10.8 Summary and Conclusions.References.11 Monolithic Stationary Phases for Fast Ion Chromatography (Pavel N. Nesterenko and Paul R. Haddad).11.1 Fast Ion Chromatography.11.2 Historical Development of Fast Ion Chromatography.11.4 Type and Properties of Silica Monolithic Columns Used in IC 212.11.5 Modification of Silica Monoliths for IC Separations.11.6 Operational Parameters.11.7 Analytical Applications.11.8 Future Work.References.12 Monolithic Chiral Stationary Phases for Liquid-Phase Enantioseparation Techniques (Bezhan Chankvetadze).12.1 Introduction.12.2 Organic Monolithic Materials for the Separation of Enantiomers.12.3 Silica-Based Monolithic Materials for the Separation of Enantiomers.12.4 Summary of the Present State-of-the-Art and Problems to be Solved in the Future.References.13 High-Speed and High-Effi ciency Separations by Utilizing Monolithic Silica Capillary Columns (Takeshi Hara, Kosuke Miyamoto, Satoshi Makino, Shohei Miwa, Tohru Ikegami, Masayoshi Ohira, and Nobuo Tanaka).13.1 Introduction.13.2 Preparation of Monolithic Silica Capillary Columns.13.3 Properties of Monolithic Silica Capillary Columns.13.4 Monolithic Silica Capillary Columns for High-Efficiency Separations.13.5 Monolithic Silica Capillary Columns for High-Speed Separations.13.6 Future Considerations.13.7 Conclusion.References.14 Silica Monolithic Columns and Mass Spectrometry (Keith Ashman).14.1 Introduction.14.2 Offline Chromatography, LC MALDI MS.14.3 Online ESI LC/MS/MS for Proteomics and Selected Reaction Monitoring (SRM).14.4 Online Reactors and Affinity Columns Coupled to Mass Spectrometry.14.5 Conclusion.References.15 Silica Monoliths for Small-Scale Purification of Drug-Discovery Compounds (Alfonso Espada, Cristina Anta, and Manuel Molina-Martin).15.1 Introduction.15.2 Instrumental and Operating Considerations.15.3 Preparative Separations and Sample Loading.15.4 Purification of Drug-Discovery Compounds.15.5 Conclusions.Acknowledgment.&l Other Applications of Silica Monolith.17.5 Conclusion and Outlook.References.Index. Monolithic Silicas in Separation Science: InhaltsangabePreface.List of Contributors.1 The Basic Idea and the Drivers (Nobuo Tanaka and Klaus K. Unger).1.1 Definitions.1.2 Monoliths as Heterogeneous Catalysts.1.3 Monoliths in Chromatographic Separations.1.4 Conclusion and Perspectives.References.Part One Preparation.2 Synthesis Concepts and Preparation of Silica Monoliths (Kazuki Nakanishi).2.1 Introduction.2.2 Background and Concepts.2.3 Synthesis of Silica Monoliths.2.4 Monolithic Columns Prepared in the Laboratory.2.5 Summary.References.3 Preparation and Properties of Various Types of Monolithic Silica Stationary Phases for Reversed-Phase, Hydrophilic Interaction, and Ion-Exchange Chromatography Based on Polymer-Coated Materials (Oscar Nunez and Tohru Ikegami).3.1 Stationary Phases for Reversed-Phase Chromatography.3.2 Stationary Phases for Hydrophilic-Interaction Chromatography Separations.3.3 Stationary Phases for Ion-Exchange Separations.3.4 Advantages of Polymer-Coated Monolithic Silica Columns.References.Part Two Characterization and Modeling.4 Characterization of the Pore Structure of Monolithic Silicas (Romas Skudas, Matthias Thommes, and Klaus K. Unger).4.1 Monolithic Silicas.4.2 General Aspects Describing Porous Materials.4.3 Characterization Methods of the Pore Structure of Monolithic Silicas.4.4 Comparison of the Silica Monolith Mesopore-Characterization Data.4.5 Comparison of the Silica Monolith Flow-Through Pore-Characterization Data.References.5 Microscopic Characterizations (Haruko Saito, Kazuyoshi Kanamori, and Kazuki Nakanishi).5.1 Introduction.5.2 Preparation of Macroporous Silica Monolith.5.3 Laser Scanning Confocal Microscope Observation.5.4 Image Processing.5.5 Fundamental Parameters.5.6 Three-Dimensional Observation of Deformations in Confined Geometry.References.6 Modeling Chromatographic Band Broadening in Monolithic Columns (Frederik Detobel and Gert Desmet).6.1 Introduction.6.2 The General Plate-Height Model.6.3 Use of the General Plate-Height Model to Predict Band Broadening in TSM Structures.6.4 Conclusion.Acknowledgments.Symbols.Greek Symbols.Subscripts.References.7 Comparison of the Performance of Particle-Packed and Monolithic Columns in High-Performance Liquid Chromatography (Georges Guiochon).7.1 Introduction.7.2 Basic Columns Properties.7.3 Comparison of the Through-Pore Structures and Related Properties.7.4 Thermodynamic Properties.7.5 Kinetic Propertie Solutes.9.4 Contribution of Overload to Peak Shapes of Basic Solutes.9.5 Van Deemter Plots for Commercial Monoliths.9.6 Performance of Hybrid Capillary Silica Monoliths for Basic Compounds.9.7 Conclusions.References.10 Quality Control of Drugs (Mohammed Taha, Abdelkarem Abed, and Sami El Deeb).10.1 Introduction.10.2 Analysis of Pharmaceutics.10.3 Natural Products Analysis.10.4 Analysis Speed and Performance.10.5 Method Transfer.10.6 Separation of Complex Mixtures.10.7 Monolith Derivatives and Versatile Application.10.8 Summary and Conclusions.References.11 Monolithic Stationary Phases for Fast Ion Chromatography (Pavel N. Nesterenko and Paul R. Haddad).11.1 Fast Ion Chromatography.11.2 Historical Development of Fast Ion Chromatography.11.4 Type and Properties of Silica Monolithic Columns Used in IC 212.11.5 Modification of Silica Monoliths for IC Separations.11.6 Operational Parameters.11.7 Analytical Applications.11.8 Future Work.References.12 Monolithic Chiral Stationary Phases for Liquid-Phase Enantioseparation Techniques (Bezhan Chankvetadze).12.1 Introduction.12.2 Organic Monolithic Materials for the Separation of Enantiomers.12.3 Silica-Based Monolithic Materials for the Separation of Enantiomers.12.4 Summary of the Present State-of-the-Art and Problems to be Solved in the Future.References.13 High-Speed and High-Effi ciency Separations by Utilizing Monolithic Silica Capillary Columns (Takeshi Hara, Kosuke Miyamoto, Satoshi Makino, Shohei Miwa, Tohru Ikegami, Masayoshi Ohira, and Nobuo Tanaka).13.1 Introduction.13.2 Preparation of Monolithic Silica Capillary Columns.13.3 Properties of Monolithic Silica Capillary Columns.13.4 Monolithic Silica Capillary Columns for High-Efficiency Separations.13.5 Monolithic Silica Capillary Columns for High-Speed Separations.13.6 Future Considerations.13.7 Conclusion.References.14 Silica Monolithic Columns and Mass Spectrometry (Keith Ashman).14.1 Introduction.14.2 Offline Chromatography, LC MALDI MS.14.3 Online ESI LC/MS/MS for Proteomics and Selected Reaction Monitoring (SRM).14.4 Online Reactors and Affinity Columns Coupled to Mass Spectrometry.14.5 Conclusion.References.15 Silica Monoliths for Small-Scale Purification of Drug-Discovery Compounds (Alfonso Espada, Cristina Anta, and Manuel Molina-Martin).15.1 Introduction.15.2 Instrumental and Operating Considerations.15.3 Preparative Separations and Sample Loading.15.4 Purification of Drug-Discovery Compounds.15.5 Conclusions.Acknowledgment.&l Other Applications of Silica Monolith.17.5 Conclusion and Outlook.References.Index. Chromatographie, Wiley-VCH<

2010, ISBN: 9783527633258

Concepts, Syntheses, Characterization, Modeling and Applications, eBooks, eBook Download (PDF), 1. Auflage, [PU: Wiley-VCH], Wiley-VCH, 2010

2010, ISBN: 9783527633258

Concepts, Syntheses, Characterization, Modeling and Applications, [ED: 1], 1., Auflage, eBook Download (PDF), eBooks, [PU: Wiley-VCH]

2010, ISBN: 9783527633258

Concepts, Syntheses, Characterization, Modeling and Applications, [ED: 1], 1. Auflage, eBook Download (PDF), eBooks, [PU: Wiley-VCH]

2010, ISBN: 9783527633258

Concepts, Syntheses, Characterization, Modeling and Applications, [ED: 1], Auflage, eBook Download (PDF), eBooks, [PU: Wiley-VCH]