2010, ISBN: 3838117719

[EAN: 9783838117713], Neubuch, [PU: Südwestdeutscher Verlag Für Hochschulschriften AG Co. KG], nach der Bestellung gedruckt Neuware - Printed after ordering - This thesis deals with the p… Mehr…

[EAN: 9783838117713], Neubuch, [PU: Südwestdeutscher Verlag Für Hochschulschriften AG Co. KG], nach der Bestellung gedruckt Neuware - Printed after ordering - This thesis deals with the preparation microparticles by spray-freeze-drying (SFD). As the process consists of various unit operations, the stability of labile APIs, such as proteins, can be serverly impaired. The secondary structure of a protein is known to be directly linked to its overall stability. However, quantification of protein secondary structure by FTIR spectroscopy can show poor reproducibility. Therefore, the first part of this thesis covers the development of a new FTIR method for objective and fast determination of protein secondary structure. The second part investigates the influence of atomization conditions on protein secondary and tertiary structure as well as residual enzyme activity during SFD. The process is analyzed after a) atomization b) atomization, freezing and thawing and c) the complete SFD process. A thorough comparison of the utilized ultrasound nozzles (including particle size distribution, temperatures and cavitation effects) is performed in the third part of this thesis. In the fourth and last part, different formulations containing a mixture of alpha-chymotrypsin and various excipients are evaluated for their stability. 188 pp. Englisch, Books<

2015, ISBN: 9783838117713

[ED: Taschenbuch], [PU: Südwestdeutscher Verlag für Hochschulschriften AG Co. KG], This thesis deals with the preparation microparticles by spray-freeze-drying (SFD). As the process consi… Mehr…

[ED: Taschenbuch], [PU: Südwestdeutscher Verlag für Hochschulschriften AG Co. KG], This thesis deals with the preparation microparticles by spray-freeze-drying (SFD). As the process consists of various unit operations, the stability of labile APIs, such as proteins, can be serverly impaired. The secondary structure of a protein is known to be directly linked to its overall stability. However, quantification of protein secondary structure by FTIR spectroscopy can show poor reproducibility. Therefore, the first part of this thesis covers the development of a new FTIR method for objective and fast determination of protein secondary structure. The second part investigates the influence of atomization conditions on protein secondary and tertiary structure as well as residual enzyme activity during SFD. The process is analyzed after a) atomization b) atomization, freezing and thawing and c) the complete SFD process. A thorough comparison of the utilized ultrasound nozzles (including particle size distribution, temperatures and cavitation effects) is performed in the..., DE, [SC: 0.00], Neuware, gewerbliches Angebot, 188, [GW: 298g], Banküberweisung, PayPal, Klarna-Sofortüberweisung, [CT: Sonstiges / Sonstiges]<

2015, ISBN: 9783838117713

[ED: Taschenbuch], [PU: Südwestdeutscher Verlag für Hochschulschriften AG Co. KG], This thesis deals with the preparation microparticles by spray-freeze-drying (SFD). As the process consi… Mehr…

[ED: Taschenbuch], [PU: Südwestdeutscher Verlag für Hochschulschriften AG Co. KG], This thesis deals with the preparation microparticles by spray-freeze-drying (SFD). As the process consists of various unit operations, the stability of labile APIs, such as proteins, can be serverly impaired. The secondary structure of a protein is known to be directly linked to its overall stability. However, quantification of protein secondary structure by FTIR spectroscopy can show poor reproducibility. Therefore, the first part of this thesis covers the development of a new FTIR method for objective and fast determination of protein secondary structure. The second part investigates the influence of atomization conditions on protein secondary and tertiary structure as well as residual enzyme activity during SFD. The process is analyzed after a) atomization b) atomization, freezing and thawing and c) the complete SFD process. A thorough comparison of the utilized ultrasound nozzles (including particle size distribution, temperatures and cavitation effects) is performed in the..., DE, [SC: 0.00], Neuware, gewerbliches Angebot, 188, [GW: 298g], Banküberweisung, PayPal, Klarna-Sofortüberweisung, [CT: Sonstiges / Sonstiges]<

2010, ISBN: 3838117719

[EAN: 9783838117713], Neubuch, [PU: Südwestdeutscher Verlag für Hochschulschriften], MEDIZIN SPRAY-FREEZE-DRYING MICROPARTICLE FTIR SPECTROSCOPY PROTEIN FORMULATION ATOMIZATION ULTRASOUND… Mehr…

[EAN: 9783838117713], Neubuch, [PU: Südwestdeutscher Verlag für Hochschulschriften], MEDIZIN SPRAY-FREEZE-DRYING MICROPARTICLE FTIR SPECTROSCOPY PROTEIN FORMULATION ATOMIZATION ULTRASOUND EIWEISS, Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Autor/Autorin: Vonhoff SebastianSebastian Vonhoff passed his licensing exam as German pharmacistin 2006. From 2006 - 2009 he did his PhD thesis under thesupervision of Prof. Dr. Geoffrey Lee at the Division ofPharmaceutics (University Erlangen-Nure., Books<

2010, ISBN: 3838117719

[EAN: 9783838117713], Neubuch, [PU: Suedwestdeutscher Verlag fuer Hochschulschriften], Clean and crisp and new!, Books