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MLH1 and MSH2 as Potential Biomarkers of Risk for Colorectal Cancer - Results of a pilot investigation of DNA mismatch repair proteins - Sidelnikov, Eduard
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MLH1 and MSH2 as Potential Biomarkers of Risk for Colorectal Cancer - Results of a pilot investigation of DNA mismatch repair proteins - Taschenbuch

2010, ISBN: 9783838386676

[ED: Taschenbuch / Paperback], [PU: LAP Lambert Academic Publishing], Colorectal cancer is the third most common incident cancer in the United States and the second cause of cancer deaths… Mehr…

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MLH1 and MSH2 as Potential Biomarkers of Risk for Colorectal Cancer - Results of a pilot investigation of DNA mismatch repair proteins - Sidelnikov, Eduard
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Sidelnikov, Eduard:

MLH1 and MSH2 as Potential Biomarkers of Risk for Colorectal Cancer - Results of a pilot investigation of DNA mismatch repair proteins - Taschenbuch

2010, ISBN: 9783838386676

[ED: Taschenbuch / Paperback], [PU: LAP Lambert Academic Publishing], Colorectal cancer is the third most common incident cancer in the United States and the second cause of cancer deaths… Mehr…

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MLH1 and MSH2 as Potential Biomarkers of Risk for Colorectal Cancer - Eduard Sidelnikov
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Eduard Sidelnikov:
MLH1 and MSH2 as Potential Biomarkers of Risk for Colorectal Cancer - Taschenbuch

ISBN: 9783838386676

[ED: Taschenbuch], [PU: LAP Lambert Academic Publishing], Neuware - Colorectal cancer is the third most common incident cancer in the United States and the second cause of cancer deaths i… Mehr…

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Sidelnikov, E: MLH1 and MSH2 as Potential Biomarkers of Risk - Eduard Sidelnikov
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Eduard Sidelnikov:
Sidelnikov, E: MLH1 and MSH2 as Potential Biomarkers of Risk - Taschenbuch

2010, ISBN: 9783838386676

Colorectal cancer is the third most common incident cancer in the United States and the second cause of cancer deaths in men and women combined. Impairment of DNA mismatch repair (MMR) me… Mehr…

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MLH1 and MSH2 as Potential Biomarkers of Risk for Colorectal Cancer
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MLH1 and MSH2 as Potential Biomarkers of Risk for Colorectal Cancer - neues Buch

ISBN: 9783838386676

Colorectal cancer is the third most common incident cancer in the United States and the second cause of cancer deaths in men and women combined. Impairment of DNA mismatch repair (MMR) me… Mehr…

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Details zum Buch
MLH1 and MSH2 as Potential Biomarkers of Risk for Colorectal Cancer

Colorectal cancer is the third most common incident cancer in the United States and the second cause of cancer deaths in men and women combined. Impairment of DNA mismatch repair (MMR) mechanisms in colonocytes is responsible for about 15% of colorectal cancers. MLH1 and MSH2 proteins play a crucial role in DNA MMR and loss of expression of either (or both) of these proteins is the main cause of DNA MMR insufficiency. These pilot data suggest that lower MLH1 and MSH2 expression in the normal colonic mucosa, at least in the ascending colon, may be associated with increased risk of incident, sporadic colorectal adenoma as well as with modifiable risk factors for colorectal neoplasms, specifically, regular use of NSAIDs. Higher calcium and vitamin D intakes result in increased DNA MMR system activity in the normal colorectal mucosa of sporadic adenoma patients, and the strongest effects may be vitamin D related. These data support further investigation of MLH1 and MSH2 expression as potential modifiable biomarkers of risk for colorectal neoplasms. This work would be interesting for molecular epidemiologists and cancer researchers.

Detailangaben zum Buch - MLH1 and MSH2 as Potential Biomarkers of Risk for Colorectal Cancer


EAN (ISBN-13): 9783838386676
ISBN (ISBN-10): 3838386671
Gebundene Ausgabe
Taschenbuch
Erscheinungsjahr: 2010
Herausgeber: LAP Lambert Acad. Publ.
156 Seiten
Gewicht: 0,244 kg
Sprache: eng/Englisch

Buch in der Datenbank seit 2007-05-30T02:30:57+02:00 (Vienna)
Detailseite zuletzt geändert am 2020-10-14T23:45:49+02:00 (Vienna)
ISBN/EAN: 9783838386676

ISBN - alternative Schreibweisen:
3-8383-8667-1, 978-3-8383-8667-6


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